Mesalamine does not cause some of the negative side effects associated with sulfasalazine because the chemical structure is made up of the 5 ASA chemical group without the sulfa group walmart priligy The mouse model of sporadic CRC is based on allelic inactivation of one copy of the Apc tumor suppressor gene in colonic epithelial cells that is driven by a Cdx2 Cre transgene Cdx2 Cre Apc F 24, 27